![]() ![]() ![]() ![]() As potential targets for discovery of therapeutic agents, the two cysteine proteases that are responsible for cleaving the polyproteins have been highlighted, namely, the chymotrypsin-like or main protease, known as 3CL pro or M pro, and the papain-like protease, PL pro. (2,3) After cell entry, viral RNA is translated by host ribosomes into two polyproteins that are cleaved to produce the viral proteins that are needed for assembling new virions. The coronavirus SARS-CoV-2, the cause of the COVID-19 pandemic, (1) encodes several enzymes that are essential to its ability to replicate.
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